甲状腺 peroxidase antibody

定义

甲状腺 peroxidase is a type of protein (called an 酶) that cells in the thyroid gland use to make thyroid hormone. If these 酶s leak out into the bloodstream (as when thyroid cells are damaged) the immune system makes 抗体 对抗这些蛋白质. The thyroid peroxidase antibody test measures these 抗体 in the blood.

选择的名字

甲状腺 antimicrosomal antibody; Antimicrosomal antibody; Microsomal antibody; Antithyroid microsomal antibody; TPOAb; Anti-TPO antibody

How the Test is Performed

A 血液样本 是必要的.

考试的感觉如何

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. 这很快就会消失.

Why the Test is Performed

This test is done to confirm the cause of thyroid problems, including 桥本甲状腺炎.

The test is also used to find out if an immune or 自身免疫性疾病 正在损害甲状腺.

正常的结果

A negative test means the result is normal.

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different specimens. Talk to your health care provider about the meaning of your specific test results.

What Abnormal Results Mean

A positive test may be due to:

• Granulomatous or subacute thyroiditis (an immune reaction of the thyroid gland that often follows an upper respiratory infection)
• 桥本甲状腺炎 (a reaction of the immune system against the thyroid gland)

High levels of these 抗体 have also been linked with an increased risk of:

• 流产
• 子痫前期 (high blood pressure and protein in the urine after the 20th week of pregnancy)
• 早产
• 体外受精 失败

Important: A positive result does not always mean that you have a thyroid condition or that you need treatment for your thyroid. A positive result may mean that you have a higher chance of developing thyroid disease in the future. This is often associated with a family history of thyroid disease.

Antithyroid microsomal 抗体 may be seen in your blood if you have other autoimmune conditions, 包括:

• Autoimmune hemolytic anemia
• 自身免疫性肝炎
• Autoimmune adrenal disease
• 类风湿性关节炎
• 干燥综合症
• Systemic lupus erythematosus

风险

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a 血液样本 from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight, but may include:

• 大出血
• Fainting or feeling lightheaded
• Multiple punctures to locate veins
• 血肿 (blood buildup under the skin)
• Infection (a slight risk any time the skin is broken)

参考文献

Brent GA, Weetman AP. Hypothyroidism and thyroiditis. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14日艾德. Philadelphia, PA: Elsevier; 2020:chap 13.

Guber HA, Oprea M, Russell YX. Evaluation of endocrine function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24日艾德. Philadelphia, PA: Elsevier; 2022:chap 25.

Pearce EN, Hollenberg AN. 甲状腺. In: Goldman L, Cooney KA, eds. Goldman-Cecil医学. 27日,艾德. Philadelphia, PA: Elsevier; 2024:chap 207.

Ramos-Levi AM, Marazuela M. 甲状腺炎. In: Robertson RP, ed. DeGroot的内分泌学. 8日艾德. Philadelphia, PA: Elsevier; 2023:chap 73.

史密斯JR，沃斯纳AJ. 甲状腺炎. 在:Kliegman RM, St. Geme JW, Blum NJ, et al, eds. Nelson Textbook of Pediatrics. 22日艾德. Philadelphia, PA: Elsevier; 2025:chap 604.